POMI-T. More Broccoli please!

I love juicing! However a recent talk by an integrative oncologist emphasised the importance of diet rotation. I needed a bit of that to prevent the tumour outflanking my defences!

I decided to cut back on carrot and beetroot juice – the sugar content was a concern – I would juice with less sugary fruit and vegetables. What could I juice then? As luck would have it I came across the POMI-T study (http://www.pomi-t.com/Pomi-T-Paper.pdf) which in my opinion is massive:

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This randomised controlled trial investigated patients with prostate cancer. The patients in the active treatment group took a pill containing:

  • broccoli powder (Brassica oleracea) 100 mg,
  • turmeric powder (Curcuma longa) 100 mg,
  • pomegranate whole fruit powder (Punica granatum) 100 mg,
  • green tea 5:1 extract (Camellia sinensis) 20 mg equivalent to 100 mg of green tea and
  • bulking agent (di-calcium phosphate), anti-caking agents (modified maize-based starch, maltodextrin and magnesium stearate) removed post trial.

The change in prostate specific antigen (PSA) over six months was studied. A control group was given placebo. Well – you certainly wouldn’t want to have been in the placebo group! Even in this small-ish study involving 200 patients a highly significant benefit was seen in patients who took the POMI-T pill. The PSA rise was pretty small whereas in the untreated group a massive 78% rise occurred. The anti-cancer effect does not seem to be mediated through a hormonal mechanism.

What does this mean? Well it is not a clinical outcome study so we don’t really know if the findings correspond to a real benefit to the patients. HOWEVER! All the ingredients may be purchased down my local high street – the wonderful Gloucester Road. Difficult not to buy some pomegranates, curcumin root, broccoli and juice away to my heart’s content. Green tea mid afternoon and Bob’s your uncle, as they say…

Here is a link to a web-page concerning POMI-T with a very excellent youtube clip of Professor Robert Thomas who led the trial:

http://www.nutraingredients.com/Research/Diet-and-cancer-Polyphenol-trial-data-suggests-significant-clinical-benefit-for-prostate-cancer

A word of caution: Curcumin has side effects and can thin the blood and may rarely trigger gallstones in susceptible individuals. Also broccoli can affect vitamin K metabolism – patients taking blood thinners need to be careful. So best to discuss with one’s doctor if considering this treatment.

Today marks 3 years since I found a lump..

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A 3 year Cancer-versary! I am feeling positive and everything seems stable. All power to the NHS for putting the fire out! But then it’s been over to natural chemotherapy – curcumin, artemisinin, vitamin D, a vegan low sugar diet and much much more. The orthodox docs still see me as a good advert for chemo but I am outside the 95% confidence intervals for survival for this rare as hen’s teeth condition. At times – following some of the cancer stories – there has been sadness as others have not been so lucky….

Currently I am concentrating on the emotional side – wow! I really rate EFT (Emotional Freedom Technique) and hypnotherapy. A real eye opener!

 

So – to celebrate here is an uplifting song!!!!

Can’t stop the Feeling!!!

Would write more but it’s sauna time….

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis

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A wordy title! No wonder patients feel confused when conversing with doctors!

This was the first article that caught my eye in December’s issue of the BMJ:

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and  network meta-analysis:

BMJ 2016355 doi: http://dx.doi.org/10.1136/bmj.i6188 (Published 05 December 2016)Cite this as: BMJ 2016;355:i6188

Meta-analysis is a research method that pools results of similar small studies creating a large body of data from numerous patients – this makes for much more powerful statistics in the right hands. Unfortunately, this paper is very difficult to read and understand. The authors use a lot of abbreviations, acronyms and medical jargon. When I was reviewing papers I would have used a lot of red ink on this one!! This paper looks at patients followed over a 3-5 year period.

Early on in my journey I asked my oncologist what else I should be doing to prevent the tumour returning. Were there some commonly available medicines which might help me? The oncologist mentioned aspirin. Early stage research suggested that aspirin can protect against cancer and possibly its recurrence. However, large randomised trials were not available to give a definitive answer. My oncologist looked at me sidelong while discussing this and tempered his remarks by saying that I was probably at risk of bleeding from the bowel, so on balance best to avoid aspirin.

So, is it possible to prevent colorectal cancer in individuals with a previous history by using some commonly available medicines – NSAIDS or non-steroidal anti-inflammatory drugs (celecoxib and sulindac which are similar to ibuprofen were used in these trials), low and high dose aspirin, calcium and vitamin D, folate? More importantly does the benefit outweigh the risk?

The meta-analysis includes adult patients with previous colorectal neoplasia (i.e. tumours – could be simple or metaplastic polyps or cancer – the paper itself does not specify). Studies were randomised controlled trials of placebo versus an active medication or combination of drugs.

I am unable to reproduce the figures due to copyright but summarising the findings:

NSAIDs were most effective at preventing colorectal cancer but gave most side effects. Of course the most feared side effects of drugs like these (serious side effects are significant but thankfully infrequent) are gastro-intestinal bleeding and kidney failure – so not to be taken lightly.

Aspirin was also very effective especially at the high doses of 160mg. The lower dose 81mg was also effective and had a better track record for side effects.

Calcium supplementation was not very effective and gave a lot of side effects

Folate was not very effective but there were few side effects

Vitamin D was not very effective and there were few side effects. The study doesn’t give the vitamin D doses. One has to delve into the individual referenced papers. The two papers studying vitamin D were quite small and the doses were also rather minute – 20 IU  dailyin Baron et al 2015 and 1000 IU daily in Pommegard et al. 2016. Due to the small numbers of patients given vitamin D alone, I don’t think any real conclusions can be drawn.

Summarising NSAIDs were the most effective but the risks are high. Low dose aspirin had the best risk:benefit profile. However, I don’t feel this paper is sufficiently powered to allow conclusions to be made about calcium, vitamin D or folate.

An Alternative Partridge

 

I was rather late with Christmas cards this year – so here is a late Christmas message to everyone:

On the First day of Christmas my true love sent to me a mug full of golden milk. 

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On the Second day of Christmas my true love sent to me, two ginger roots and a mug full of golden  milk. 

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On the Third day of Christmas my true love sent to me three raw salads, two ginger roots and a mug full of golden milk. 

On the Fourth day of Christmas my true love sent to me 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk. 

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On the Fifth day of Christmas my true love sent to me, five Brussels sprouts, 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk.

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On the Sixth day of Christmas my true love sent to me, six sauna sessions, five Brussel sprouts, 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk.

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On the Seventh day of Christmas my true love sent to me seven chaga mushrooms, six sauna sessions, five Brussel sprouts, 4 garlic cloves, three raw salads, two ginger roots and a a mug full of golden milk.chaga-mushroom

 

On the Eighth day of Christmas my true love sent to me eight healers healing, seven chaga mushrooms, six sauna sessions, five Brussel sprouts , 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk.

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On the Ninth day of Christmas my true love sent to me nine juicers juicing, eight healers healing, seven chaga mushrooms, six sauna sessions, five Brussel sprouts, 4 garlic cloves, three tofu chunks, two ginger roots and a mug full of golden milk.

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On the Tenth day of Christmas my true love sent to me ten chilli peppers, nine juicers juicing, eight healers healing, seven chaga mushrooms, six sauna sessions, five Brussel sprouts, 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk.

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On the Eleventh day of Christmas my true love sent to me Low Dose Naltrexone, ten chilli peppers, nine juicers juicing, eight healers healing, seven chaga mushrooms, six sauna sessions, five Brussel sprouts, 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk.  

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On the Twelfth day of Christmas my true love sent for me twelve thoughtful prayers, Low Dose Naltrexone, ten chilli peppers, nine juicers juicing, eight healers healing, seven chaga mushrooms, six sauna sessions, five Brussel sprouts, 4 garlic cloves, three raw salads, two ginger roots and a mug full of golden milk.

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